Telomere Staining Kit - メーカー・企業と業務用製品 | イプロスものづくり

[PIPA] Telomere Staining Kit

This is a reagent (kit) for the specific visualization of telomeres.

We have developed a polyamide that specifically stains the telomeres of chromosomes, and it has now been commercialized as a kit. The repetitive region of simple base sequences located at the ends of chromosomes is referred to as telomeres, which in vertebrates consists of the repeat sequence (TTAGGG). It has been hypothesized that the length of telomeres is related to cancer and aging (progeria) in individuals, increasing their importance as targets for molecular imaging. A method for detecting telomere DNA on chromosomes using fluorescently labeled peptide nucleic acid (PNA) probes with fluorescence in situ hybridization (FISH) is known; however, PNA is difficult to transfer into cells. A tandem polyamide that specifically binds to the repeat sequence (TTAGGG) of vertebrate telomeres has been reported (2001). By using the fluorescently labeled HPTH59, it is possible to fluorescently stain telomere DNA much more simply and quickly than with PNA FISH or Southern blotting techniques.